Vetalog

Vetalog Parenteral is indicated for the treatment of inflammation and related disorders in dogs cats and horses. It is also indicated for use in dogs and cats for the management and treatment of acute arthritis allergic and dermatologic disorders.

Vetalog Parenteral (Sterile Triamcinolone Acetonide Suspension USP) is available for veterinary use as a sterile suspension in vials providing 2 mg triamcinolone acetonide per mL with 0.9% (w/v) benzyl alcohol as a preservative sodium chloride for isotonicity 0.75% carboxymethylcellulose sodium and 0.04% polysorbate 80. Sodium hydroxide or hydrochloric acid may have been added to adjust the pH. At the time of manufacture the air in the container is replaced by nitrogen. 25 ml

For dogs and cats.

RATIONALE FOR USE
Inflammation and Related Disorders
Dogs Cats and Horses
Injection of Vetalog Parenteral provides rapid relief from pain and reduces inflammation and swelling.
Depending on the nature of the condition Vetalog Parenteral may be injected intramuscularly intra-articularly or intrasynovially. The usual pattern of response is improvement of motion and decrease of pain within 24 hours followed by diminution of swelling.
The extent of return to normal is limited by the degree of irreversible pathologic change present. Triamcinolone acetonide will not reverse permanent pathologic changes.
Allergic and Dermatologic Disorders
Dogs and Cats
Intramuscular or subcutaneous administration of Vetalog Parenteral (Sterile Triamcinolone Acetonide Suspension USP) has been found to provide prompt and prolonged relief in the management of allergic symptoms such as conjunctivitis or reactions to insect bites and in various dermatoses. Inflammation edema and pruritus are suppressed and discomfort is eased usually within 24 hours. Since scratching is reduced or eliminated lesions are permitted to heal more rapidly. In many cases a single injection is sufficient to terminate symptomatology. If necessary repeat treatments can be administered.
Intralesional administration of Vetalog Parenteral is effective for treatment of dermatological disorders such as moist eczema frictional acanthosis and other dermatitides in dogs and cats. Inflammation and pruritus are often abated within one to three days. A single intralesional injection is often sufficient to effect remission or elimination of the lesion within a period of one to two weeks.

CONTRAINDICATIONS
Do not use in viral infections. Except for emergency therapy do not use in animals with tuberculosis chronic nephritis or cushingoid syndrome. Existence of congestive heart failure diabetes and osteoporosis are relative contraindications.

WARNINGS
Not for use in horses intended for food.

USAGE IN PREGNANCY
The safety of most corticosteroid drugs for use during all stages of pregnancy has not been adequately established. However clinical and experimental data have demonstrated that corticosteroids administered orally or by injection to animals may induce the first stage of parturition if used during the last trimester of pregnancy and may precipitate premature parturition followed by dystocia fetal death retained placenta and metritis.
Additionally corticosteroids administered to dogs rabbits and rodents during pregnancy have resulted in cleft palate in offspring. Corticosteroids administered to dogs during pregnancy have also resulted in other congenital anomalies including deformed forelegs phocomelia and anasarca. Therefore before use of corticosteroids in pregnant animals the possible benefits to the pregnant animal should be weighed against potential hazards to its developing embryo or fetus.

PRECAUTIONS
Vetalog Parenteral (Sterile Triamcinolone Acetonide Suspension USP) should not be used to alleviate pain or reduce inflammation arising from infectious states unless concomitant antimicrobial therapy is given.
Because of the anti-inflammatory action of corticosteroids signs of infection may be hidden and it may be necessary to stop treatment until diagnosis is made.
Overdosage of some glucocorticoids may result in sodium retention fluid retention potassium loss and weight gains.
Corticosteroids have been used in the treatment of laminitis; Vetalog Parenteral (Sterile Triamcinolone Acetonide Suspension USP) is not recommended for that use. Cases of laminitis have been reported following the administration of Vetalog Parenteral (Sterile Triamcinolone Acetonide Suspension USP); the mechanism of that response has not been fully elucidated. Care is necessary when using any corticosteroid in the equine species.
Use of corticosteroids depending on dose duration and specific steroid may result in inhibition of endogenous steroid production following drug withdrawal. In patients presently receiving or recently withdrawn from systemic corticosteroid treatments therapy with a rapidly acting corticosteroid should be considered in unusually stressful situations.

ADVERSE REACTIONS
As with any corticosteroid polydipsia or polyuria may occur with high dosage or frequent administration of triamcinolone acetonide. The likelihood of their occurrence may be minimized by giving as brief a course of corticosteroid therapy as possible and by waiting for the reappearance of symptoms before repeating therapy. If polydipsia or polyuria should occur therapy should be discontinued until these unwanted effects have disappeared; therapy should then be resumed at a lower dosage level.
Other adverse reactions that have occurred with the use of corticosteroids are weight loss anorexia and diarrhea (occasionally bloody). Anaphylacoid reactions have occasionally been seen following administration.
Intra-articular injection in leg injuries of the horse may produce osseous metaplasia.
Side effects such as serum alkaline phosphatase (SAP) and serum glutamic pyruvic transaminase (SGPT) enzyme elevations have occurred following use of synthetic corticosteroids in dogs.
Cushing's Syndrome in dogs has been reported in association with prolonged or repeated steroid therapy.

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