Prednisone

Prednisone is a synthetic corticosteroid.

Prednisone tablets are indicated in the following conditions:

• Endocrine disorders
  
• Rheumatic disorders
  
• Collagen diseases
  
• Dermatologic diseases
  
• Allergic states
  
• Ophthalmic diseases
  
• Respiratory diseases
  
• Hematologic disorders
  
• Neoplastic diseases
  
• Edematous states
  
• Gastrointestinal disease
  
• Systemic dermatomyositis (polymyositis)

Available in 5mg, 20mg and 50mg
For dogs and cats.

Prednisone tablets are indicated in the following conditions:

• Endocrine disorders: primary or secondary adrenocortical insufficiency (hydrocoritsone or cortisone is the first choice; synthetic analogs may be used in conjunction with mineralocorticoids where applicable; in infacy mineralocorticoid supplementation is of particular importance) congenital adrenal hyperplasia nonsuppurative thyroids hypercalcemia associated with cancer.
• Rheumatic disorders: as adjunctive therapy for short-term administration (to tide teh patient over an acute episode or exacerbation) in; psoriatic arthritis; rheumatoid arthritis including juvenile rheumatoid arthritis (selected cases may require low-dose maintenance therapy); ankylosing post-traumatic osteoarthritis; synovitis of osteoarthritis; epicondylitis.
• Collagen diseases: during an exacerbation or as maintenance therapy in selected cases of: systemic lupus erythematosus acute rheumatic carditis.
• Durmatologic diseases: pemphigus bullous dermatitis herpetiformis severe erythema multiforme (Stevens-Johnson syndrome) exfoilative dermatitis mycosis fungoides severe seborheic dermatitis.
• Allergic states: control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment; seasonal or perennial allergic rhinitis serum sickness bronchial asthma contact dermatitis atopic dermatitis drug hypersensitivity reactions.
• Ophthalmic diseases: severe acute and chronic allergic and inflammatory processes involving the eye and its adnexa such as: allergic conjunctivitis keratitis allergic corneal marginal ulcers herpes zoster ophthalmicus iritis and iridocyclits choriorentinitis anterior segment inflammation diffuse posterior uveitis and choroditis optic neuritis sympathetic ophthalmia.
• Respiratory diseases: dymptomatic sarcoidosis Loeffler's sydrome not manageable by other means berylliosis fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy aspiration pneumonitis.
• Hematologic disorders: Idiopathic thrombocytopenic purpura in adults secondary thrombocytopenia in adults acquired (autoimmune) hemolytic anemia eythroblastopenis (RBC anemia) congenital (erythroid) hypoplastic anemia.
• Neoplastic diseases: for palliative management of: leukemias and lymophomas in adults acute leukemia of childhood.
• Edematous states: to induce a diuresis or remission of proteinuria int he nphrotic syndrom without uremia of the idiopathic type of that due to lupus erythematosus.
• Gastointestinal disease: to tide the patient over a critical period of the disease in: ulcerative colitis regional enteritis.
• Miscellaneous: tuberculous meingitis with subarachnoid block or impending block when used concurrently with appropriate antituberculous chemotherapy trichinosis with neurologic or mycardial involvement.
• In addition to the above indications prednisone tablets are indicated for systemic dermatomyositis (polymyositis).
  

 

CONTRAINDICATIONS:
Prednisone tablets are contraindicated in systemic fungal infections.

WARNINGS:
In patients on corticosteroid therapy subjected to unusual stress increased dosage of rapidly acting corticosteroids before during and after the stressful situation is indicated.
Corticosteroids may mask some signs of infection and new infections may appear during their use. There may be decreased resistance and inability to localize infection when corticosteroids are used.
Prolonged use of corticosteroids may produce posterior subcapsular cataracts glaucoma with possible damage to the optic nerves and may enhance the establishment of secondary ocular infections due to fungi or viruses.
Average and large doses of hydrocortisone or cortisone can cause elevation of blood pressure salt and water retention and increased excreation of potassium. These effects are less likely to occur with the synthetic dervatives except when used in large doses. Dietary salt restriction and potassium supplementation may be necessary. All corticorsteroids increase calcium excretion.
While on coricorsteroid therapy patients should not be vaccinated against smallpox. Other immunization procedures should not be undertaken in patients who are on corticosteroids especially on high doses because of possible hazards of neurological complications and lack of antibody response.
Persons who are on drugs that suppress the immune system are more susceptible to infections than healthy individuals. Chichenpox and measles for example can have a more serious or evn fatal course in non-immune children or adults on corticosteroids. In such children or adults who have not had these diseases particular chare should be taken to avoid exposure. How the dose route and duration of corticosteroid administration affects teh risk of developing a disseminated infection is not known. The contribution of the underlying disease and/or prior corticosterois treatment to the risk is also not known. If exposed to chichenpox prophylaxis with varicella-zoster immune globulin (VZIG) may be indicated. If exposed to measles prophylaxis with pooled intravenous immunoglobulin (IG) may be indicated. (See the respective package inserts for complete VZIG and IG prescribing information.) If chickenpox develops treatment with antiviral agents may be considered.
The use of prednisone tablets in active tuberculosis should be restricted to those cases of fulminating or disseminated tuberculosis in which the corticosteroid is used for the management of the disease in conjunction with an appropriate antituberculous regmen.
If corticosteroids are indicated in patients with latent tuberculosis or tuberculin reactivity close observation is necessary as reactivation of hte disease may occur. During prolonged corticosteroid therapy these patients should receive chemoprophylaxis.
Usage in Pregnancy: Since adequate human reproduction studies have not been done wiht corticosteroids the use of these drugs in pregnancy nursing mothers or women of childbearing potentioal requires that the possible benefits of the drug be weighed against the potential hazzards to teh mother and embryo or fetus. Infants born of mothers who have received substatial doses of corticosteroids during pregnancy should be carefully observed for signs of hypoadrenalism.

PRECAUTIONS:
General: Drug-induced secondary adrenocortical insufficiency may be minimized by gradual reduction of dosage. This type of relative insufficiency may persist for months after discontinuation of therapy; therefore in any situation of stress occuring during that period hormone therapy should be reinstitued. Since mineralocorticoid secretion may be impaired salt and/or a mineralocorticoid should be administered concurrently.
There is an enhanced effect of corticosteroids on patients with hypothyroidism and in those with cirrhosis.
Corticosteroids should be used cautiously in patients with ocular herpes simplex because of possible coneal perforation.
The lowest possible dose of corticosteroid should be used to control the condition under treatment and when reduction in dosage is possible the reduction should be gradual.
Psychic derangements may appear when corticosteroids are used ranging from euphoria incomnia mood swings personality changes and severe depression to frank psychotic manifestations. Also existing emotional instabiltiy or phychotic tendencies may be aggravated by corticosteroids.
Asprin should be used cautiously in conjunction with corticosteroids in hypoprothrombinemia.
Steroids should be used with caution in: nonspecific ulcerative colitis if there is a probability of impending perforation abscess or other pyogenic infection; diverticulitis; fresh intestinal anastomosis; active or latent peptic ulcer; renal indefficiency; hypertension; osteoprosis; and myasthenia gravis.
Growth and development of infants and children on prolonged corticosteroid therapy should be carefully observed.

INformATION FOR PATIENTS:
Persons who are on immunosuppressant doses of corticosteroids shoudl be warned to avoid exposure to chickenpox or measles. Patients shoudl also be advised that if they are exposed medical advice shoudl be sought without delay.

ADVERSE REACTIONS:
Fluid and electrolyte dusturbances: sodium retention fluid retention congestive heart failure in susceptible patients potassium loss hypkalemic alkalosis hypertension.
Musculoskeletal: muscle weakness steroid myopathy. loss of muscle mass osteoporosis vertebral compression fractures aseptic necrosis of femoral and humeral heads pathological fractures of long bones.
Gastrointestinal: peptic ulcer with possible perforation and hemorrhage pancreatitis abdominal distention ulcerative esophagitis.
Dermatologic: impaired wound healing thin fragile skin petechiae and ecchymoses facial erythema increased sweating may suppress reactions to skin tests.
Neurological: convulsions increased intracranial pressure with papilledema (pseudotumor cerebri) usually after treatment vertigo headache.
Endocrine: menstrual irregularities; development of cushingoid state; suppression of growth in children; secondary adrenocortical and pituitary unresponsiveness particularly in times of stress as in trauma surgery or illness; decreased carbohydrate tolerance; manifestations of latent diabetes mellitus; increased requirements for insulin or oral hypoglycemic agents in diabetics.
Ophthalmic:posterior subcapsular cataracts increased intraocular pressure glaucoma exophthalmos.
Metabolic: negative nitrogen balance due to protein catabolism.

WHEN WILL THIS ITEM ARRIVE?

Warehouse Time (1 Business Day)
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Time in Transit (1-7 Business Days)
Items shipped using our standard service (ground), will arrive 1-7 days after leaving the warehouse.  Expedited shipments will arrive based on the chosen method (3 day, 2 day, overnight)

Item Arrival = Warehouse Time + Shipping Time

EXPEDITED SHIPPING
If you have chosen expedited shipping we will do our best to process the item in the quickest possible manner, and you will receive the item based on the chosen method of service (3 Day, 2 Day, overnight) an overnight order may take more than one business day for the product to arrive.