Doxirobe

Doxirobe is provided in a 2-syringe system requiring mixing prior to use. Syringe A contains the polymer delivery system (N-methyl-2-pyrrolidone and poly (DL-lactide)) and Syringe B contains the active ingredient (doxycycline). Once mixed the product is a flowable solution of doxycycline hyclate equivalent to 8.5% doxycycline activity. The formulation is applied subgingivally to the periodontal pocket(s) of affected teeth and doxycycline is slowly released from the polymer providing a local antimicrobial effect. The product is non-irritating and biodegradable.

Doxirobe is indicated for the treatment and control of periodontal disease in dogs.
 In clinical trials use of the product resulted in attachment level gains periodontal pocket depth reductions and improved gingival health. Noticeable improvements in these parameters should be evident within 2-4 weeks following treatment. The response in individual animals is dependent on the severity of the condition and rigor of adjunctive therapy. This product is not intended for use in oronasal fistulas, periapical abscesses, or severely compromised teeth.

For Dogs only.

DOSAGE AND ADMINISTRATION:
Teeth should be cleaned and scaled prior to application of the product.
If required root planing and debridement of affected sites should be performed. The product is applied with the animal under sedation or anesthesia. Use as many units as required to fill the periodontal pockets of affected teeth.

1. Each pouch contains 2 syringes and a blunt cannula. Syringe A contains the polymer delivery system and Syringe B contains doxycycline. Lock the syringes together.

   
   

2. Beginning with Syringe A use the plungers of Syringes A and B to exchange the material between the syringes approximately 100 times to achieve a consistent mixture.

   
   

3. Fully deliver the mixture into Syringe A separate the syringes and lock the supplied blunt cannula onto Syringe A. The cannula may be bent to the desired angle.

   
   

4. Gently place the cannula 1-2 mm below the gingival margin of an affected tooth. Express a small amount of the mixture into each periodontal pocket 4 mm or deeper. Ensure that the pockets are filled approximately to the gingival margin.

   
   

5. The formulation will begin to solidify immediately upon application; however lavage with a few drops of water or saline will facilitate the process. Allow approximately 30-60 seconds for the polymer to harden before beginning to press it into the pocket.

   
   

6. The exposed surface of the product may be pressed into the pocket with the edge of a wax spatula or the back of a curette. Pressure may be applied to the gingival margin to avoid dislodging the polymer inadvertently. As the product is biodegradable removal at a subsequent visit is not required.

Treatment and control of periodontal disease requires a comprehensive program of routine scaling and cleaning home care and dental hygiene (e.g. brushing rinses or the use of chewing devices) in addition to application of this product. Severe cases may require surgical intervention.
Reconstituted product not used on the day of mixing should be stored in the resealable foil pouch at room temperature (15-25°C or 59-77°F) and used within 3 days of reconstitution. Ten additional exchanges between syringes should be performed if reconstituted product has been stored.

CAUTIONS:
Do not use in dogs less than 1 year of age as the use of tetracyclines during tooth development has been associated with permanent discoloration of the teeth. Do not use in pregnant bitches. The use of the product in breeding dogs has not been evaluated.

PRECAUTION:
Clients should be advised to suspend brushing treated teeth for approximately 2 weeks following treatment.

WHEN WILL THIS ITEM ARRIVE?

Warehouse Time (1 Business Day)
After your order has been verified, we submit your order to the warehouse and it is ready to ship within 1 business day.  

Time in Transit (1-7 Business Days)
Items shipped using our standard service (ground), will arrive 1-7 days after leaving the warehouse.  Expedited shipments will arrive based on the chosen method (3 day, 2 day, overnight)

Item Arrival = Warehouse Time + Shipping Time

EXPEDITED SHIPPING
If you have chosen expedited shipping we will do our best to process the item in the quickest possible manner, and you will receive the item based on the chosen method of service (3 Day, 2 Day, overnight) an overnight order may take more than one business day for the product to arrive.